Comparative study of intra-articular injection of Platelet rich plasma Versus Corticosteroids in the treatment of early knee osteoarthritis : Clinical outcomes and urinary analysis using Urinary C-terminal telopeptide of type II collagen (uCTX-II) biomarker

Comparative study of intra-articular injection of Platelet rich plasma Versus Corticosteroids in the treatment of early knee osteoarthritis : Clinical outcomes and urinary analysis using uCTX-II biomarker

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250124005

Enrollment

Registered

2025-01-24

Start date

2024-05-27

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with primary early osteoarthritis of the knee Early OA Knee, IA-PRP, IA-CS, uCTX-II

Interventions

Intra-articular injection of Platelet rich plasma , Intra-articular injection of Corticosteroids

Experimental Drug,Active Comparator Drug

IA-PRP,IA-CS

Eligibility

Sex/Gender

All

Age

50 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Primary early osteoarthritis of the knee patients

Exclusion criteria

Exclusion criteria: 1. Allergy to cortiosteroids 2. Patients who received systemic steroids 3.Chronic kidney disease stage V

Design outcomes

Primary

Measure	Time frame
Urinary cCTX-II biomarker 0, 3 and 6 months ELISA test	—

Secondary

Measure	Time frame
Modified WOMAC score 0, 3 and 6 months Patient reported outcome using a questionnaire interview,NRS 0, 3 and 6 months Patient reported outcome using a questionnaire interview,Joint effusion, Synovial thickness 0, 3 and 6 months Ultrasonography,TUG test 0, 3 and 6 months 3 meters walk and time count by seconds	—

Countries

Thailand

Contacts

Public ContactThanapat Pakecheep

Faculty of Medicine Vajira hospital, Navamindradhiraj university

thanapat.pak@nmu.ac.th66830169857

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026