Patients with the diagnosis of ADPKD Patients with the diagnosis of ADPKD by Ravine Unified Criteria for Ultrasonographic Diagnosis of ADPKD
Conditions
Interventions
Patients with the diagnosis of ADPKD by Ravine Unified Criteria for Ultrasonographic Diagnosis of ADPKD
Diagnostic
ADPKD
Sponsors
Siriraj Research Development Fund
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with the diagnosis of ADPKD
Exclusion criteria
Exclusion criteria: Patients with other causes of cystic kidney disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference of ESRD incidence between ADPKD patients with PKD1 mutation and PKD2 mutation Time of RRT initiation Mutation analysis done by Sanger sequencing analysis, Multiplex ligationdependent probe amplification and other appropriate method may be included if needed. | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference of the rate of GFR decline between ADPKD patients with PKD1 mutation and PKD2 mutation Time of last fullow up calculation by CKD-EPI 2021 equation, using serum creatinine,Difference of total kidney volume between ADPKD patients with PKD1 mutation and PKD2 mutation Baseline calculated using the elipsoid equation by radiologist from CT or MRI kidney,Difference of renal and extra-renal manifestation between ADPKD patients with PKD1 mutation and PKD2 mutation During follow up review of medical record,Association of type of genetic mutation and clinical outcomes During follow up Mutation analysis done by Sanger sequencing analysis, Multiplex ligationdependent probe amplification and other appropriate method may be included if needed. | — |
Countries
Thailand
Contacts
Public ContactKornchanok Vareesangthip
Faculty of Medicine Siriraj hospital, Mahidol University
Outcome results
None listed