Participants who volunteer to be wounded by fractional ablative carbon dioxide laser on both inner arms to study the efficacy of timolol each method Timolol, Fractional ablative carbon dioxide 10,600-nm laser, wound healing
Conditions
Interventions
Treated with a single drop of 0.5% timolol once daily until the crusted laser wound completely healed.,Treated with a single drop of 0.5% timolol twice daily (morning and evening) until the crusted la
Experimental Drug,Experimental Drug,Experimental Drug,Active Comparator Drug,No Intervention No treatment
Area1,Area2,Area3,Area4,Area5
Sponsors
Division of Dermatology, Department of medicine, Faculty of Medicine, Ramathibodi hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Participants must be between 18 and 60 years old. 2. Participants must be in good health with no serious underlying medical conditions. 3. Participants must be able to attend scheduled appointments and follow the study protocol. 4. Participants must voluntarily agree to participate in the study by signing an informed consent form
Exclusion criteria
Exclusion criteria: 1. Participants with a history or suspected infection at the treatment site. 2. Participants with a history of keloid or hypertrophic scars. 3. Participants with a compromised immune system. 4. Participants with a history of skin cancer. 5. Participants with a history of herpes infection. 6. Participants who have taken vitamin A derivatives within the past 3 months. 7. Participants who have had laser treatment or chemical peels on the test area within the past 3 months. 8. Participants with a history of heart disease, high blood pressure, or connective tissue disorders. 9. Participants with a history of light sensitivity, allergies to timolol or other components of topical timolol, or anesthesia allergies. 10. Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy of mean lightness improvement After laser treatment, 2, 3, 7, 14, and 28 days after laser treatment mean lightness index (CIElab measurement) by colorimeter DSM III | — |
Secondary
| Measure | Time frame |
|---|---|
| Satisfactory scale, Overall healing improvement at the day 28 after laser treatment visual analog scale (0 point to 10 points),Pain score immediate after the laser treatment visual analog scale (0 point to 10 points) | — |
Countries
Thailand
Contacts
Public ContactVasanop Vachiramon
Faculty of Medicine, Ramathibodi hospital
Outcome results
None listed