The patients who were diagnosed with major depressive disorder (MDD) by DMS-5 criteria Depression, Genes, Herpesviruses, Biomarker
Conditions
Interventions
The patients who were diagnosed with major depressive disorder (MDD) by DMS-5 or ICD-10 criteria,healthy control is no current or lifetime diagnosis of any psychiatric disorder, first-degree relatives
Screening,Screening
Major depressive disorder,Healthy control
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: The patients who were diagnosed with major depressive disorder (MDD) by DMS-5 criteria or ICD-10
Exclusion criteria
Exclusion criteria: 1. Current diagnoses of other psychiatric disorders, 2. A severe depressive episode with psychotic symptoms, 3. Neurological diseases (Alzheimer's, Parkinson's, etc.), 4. Acute viral infection (HSV, VZV, CMV, etc.), 5. Autoimmune disease (rheumatoid arthritis, multiple sclerosis, asthma, etc.), 6. Chronic diseases (cancer, diabetes, heart disease, etc.) 7. Endocrine and metabolic diseases (Hypothyroidism, Hyperthyroidism, hyperparathyroidism, hypopituitarism, Addison disease, Cushing Syndrome) 8. Nutritional Disease (pellagra, pernicious anemia) 9. Hemophilia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene expression at 12 months Transcriptome sequencing | — |
Secondary
| Measure | Time frame |
|---|---|
| Risk factors at 12 months Genexepression, herpesvirus reactivation Questionnaire interviews (lifestyle, family history, clinical history, nutrition, patient health questionnaire-9 (PHQ-9), stress test questionnaire (ST-5) ) | — |
Countries
Thailand
Contacts
Public ContactAreeya Suktas
Khon Kaen University
Outcome results
None listed