Chronic immune thrombocytopenia with a platelet count of 30,000 to 100,000/mm3 Chronic immune thrombocytopenia Carica papaya Linn Median platelet count
Conditions
Interventions
Commercial Carica papaya Linn leaves capsule, 400 mg each with Thai-FDA approved.,Placebo with identical shape, color, flavor and texture.
Experimental Dietary Supplement,Placebo Comparator Dietary Supplement
Carica papaya Linn leaves,Placebo
Sponsors
Department of Medicine, Phramongkutklao Hospital Foundation
The Thai Society of Hematology
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: - Age between 18 and 60 years of age - Diagnosed of chronic primary ITP according to the American Society of Hematology 2019 Practice Guidelines for Immune Thrombocytopenia -Not received any therapy for at least 6 months before enrollment -Platelet count between 30,000 and 100,000/mm3 at the time of enrollment
Exclusion criteria
Exclusion criteria: - Patients with secondary ITP - Pregnant or lactating woman - Undergone a previous splenectomy - Patients with serum AST and ALT levels exceeding the normal upper limit - Serum creatinine level greater than 1.5 mg/dL. - Patients taking glimepiride, artesunate, digoxin, or ciprofloxacin during the therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| platelet count at visit Day 28 Platelet count by automated CBC | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety outcome every visit (Visit dat 0, 14, 21 and 28) serum BUN,Cr,LFT and other side effects,Safety outcome every visit (Visit dat 0, 14, 21 and 28) Side effects of intervention | — |
Countries
Thailand
Contacts
Public ContactTaksin Ukkahad
Phramongkutklao Hospital
Outcome results
None listed