Post-operative pain in Patients undergoing unilateral total knee arthroplasty. total knee arthroplasty, pain, dexamethasone
Conditions
Interventions
IV dexamethasone at 24 and 48 hours post-operative. Dose 0.15 mg/kg/day (max dose 12 mg/day),IV dexamethasone at 24 with dose 0.15 mg/kg/day (max dose 12 mg/day) and IV 0.9%NaCl at 48 hours post-oper
Experimental Drug,Placebo Comparator Drug
Intravenous dexamethasone used up to 48 hours post-operatively,Placebo
Sponsors
University research Management System, FACULTY OF MEDICINE VAJIRA HOSPITAL
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with Primary OA knee (Diagnosis from clinicial and radiograph) undergoing elective Unilateral Total Knee Arthroplasty
Exclusion criteria
Exclusion criteria: 1. Patients with allergic history of drug used in this study 2. Immunocompromised patients 3. Impaired cognitive function 4.Revision Surgery 5. Poor controlled diabetes mellitus (HbA1C > 8) 6. Impaired Renal Function, GRF < 30 7. Patients with history of Systemic Corticosteroid used within 3 months 8. Patients with chronic used of opioid > 3 months 9. Patients with history of gastrointestinal bleeding 10. Patients with BMI > 35
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-operative pain 24-72 hours, 14, 60, 90 days post-operative numeric rating scales | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative dose of morphine within 72 hours post-operative milligrams of morphine used,Maximum knee flexion post-operative day 1-3, 14, 60 and 90 degree | — |
Countries
Thailand
Contacts
Public ContactAffan Chesoh
Faculty of medicine Vajira hospital, Navamindrathiraj university
Outcome results
None listed