Body weight and metabolic risk reduction in obese adults with probiotics Probiotics, Obesity, Gut microbiome
Conditions
Interventions
Subjects take probiotic product 2 sachets per day for 12 weeks . Each sachet contains L. rhamnosus L34 1x 108 CFU and L45 1x 108 CFU.
,Subjects take placebo product 2 sachets per day for 12 weeks
Active Comparator Dietary Supplement,Active Comparator No treatment
Probiotics (L34andL45),Placebo
Sponsors
Program Management Unit Competitiveness(PMU-C)
Greater Pharma Company Limited
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Informed consent Age at least 18 years old BMI between 25 and 35 kg/m2 Normal fasting blood glucose (FBG below 99 mg/dL) or impaired fasting glucose ( FBG between 100 and 125 mg/dL) and HbA1C less than or equal to 6.4%
Exclusion criteria
Exclusion criteria: Diabetes mellitus Thyroid disorders Kidney disease with eGFR below 30 ml/min/1.73m2 Chronic gastrointestinal disease with acute or chronic inflammation Use of antibiotic in 3 months Pregnancy or lactation Use of medication affecting body weight i.e. steroid within 3 months Use of weight-reduction medications within 3 months Adjusting dose of antihypertensive or lipid-lowering medications within 3 months Receiving any probiotics from other source within 2 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| body weight Immediate after finish intervention and 12 weeks after intervention weight measurement | — |
Secondary
| Measure | Time frame |
|---|---|
| Body composition Immediate after finish intervention and 12 weeks after intervention Body composition measured with bioelectrical impedance (BIA) method,Metabolic profiles Immediate after finish intervention and 12 weeks after intervention Oral glucose tolerance test (OGTT) which include fasting blood glucose and 2 hr after 75g of glucose intake, lipid profile, Insulin resistance score,,Stool profiles Immediate after finish intervention and 12 weeks after intervention stool probiotics and gut microbiome,Inflammatory markers Immediate after finish intervention and 12 weeks after intervention serum cytokine and endotoxin level | — |
Countries
Thailand
Contacts
Public ContactNicha Somlaw
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed