Intraoperative local methylprednisolone for prevention of postoperative anterior thigh pain in single lateral decubitus oblique lumbar interbody fusion (OLIF): a randomized controlled trial

Methylprednisolone-soaked Gelfoam: the new intervention for postoperative anterior thigh pain in MIS-OLIF; randomized controlled trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250108001

Enrollment

Registered

2025-01-08

Start date

2023-10-30

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative anterior thigh pain postoperative anterior thigh pain Oblique lumbar interbody fusion intraoperative steroid randomized controlled trial

Interventions

3x3 cm2 Gelfoam soaked with 80 mg methylprednisolone (Solu-Medrol 40mg/ml, 2 vials) will be placed in the OLIF corridor.,3x3 cm2 Gelfoam soaked with 2 ml normal saline will be placed in the OLIF cor

Experimental Drug,Placebo Comparator Drug

Methylprednisolone-soaked Gelfoam,NSS-soaked Gelfoam

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. First time single-level OLIF operation 2. Be able to follow up at OPD for 1 year at least

Exclusion criteria

Exclusion criteria: 1. Existing preoperative anterior thigh pain 2. History of lumbar spinal fusion surgery 3. History of retroperitoneal surgery 4. History of hip joint surgery

Design outcomes

Primary

Measure	Time frame
anterior thigh pain immediate postoperative, postoperative 24 hours, 48 hours, 1 week, 2 weeks, 1 month, 3 months, 6 months and 1 year visual analog scale	—

Secondary

Measure	Time frame
psoas muscle cross-sectional area 3 month postoperative square milimeter,morphine consumption postoperative within admission milligram,Cr preoperative, postoperative 24 hours and 3 months mg/dL,CK preoperative, postoperative 24 hours and 3 months U/L,AST preoperative, postoperative 24 hours and 3 months U/L,LDH preoperative, postoperative 24 hours and 3 months U/L,ESR preoperative, postoperative 24 hours and 3 months mm/hr,CRP preoperative, postoperative 24 hours and 3 months mg/L,IL-6 preoperative, postoperative 24 hours and 3 months pg/mL,IL-1beta preoperative and postoperative 24 hours pg/mL,TNF-alpha preoperative and postoperative 24 hours pg/mL	—

Measure

Time frame

psoas muscle cross-sectional area 3 month postoperative square milimeter,morphine consumption postoperative within admission milligram,Cr preoperative, postoperative 24 hours and 3 months mg/dL,CK preoperative, postoperative 24 hours and 3 months U/L,AST preoperative, postoperative 24 hours and 3 months U/L,LDH preoperative, postoperative 24 hours and 3 months U/L,ESR preoperative, postoperative 24 hours and 3 months mm/hr,CRP preoperative, postoperative 24 hours and 3 months mg/L,IL-6 preoperative, postoperative 24 hours and 3 months pg/mL,IL-1beta preoperative and postoperative 24 hours pg/mL,TNF-alpha preoperative and postoperative 24 hours pg/mL

—

Countries

Thailand

Contacts

Public ContactKantadon Prateepswangwong

King Chulalongkorn Memorial Hospital

kantadonpunp@gmail.com0874003334

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026