Fuchs endothelial corneal dystrophy Topical Rho kinase inhibitor Ripasudil Fuchs endothelial corneal dystrophy
Conditions
Interventions
0.4% Ripasudil eye drop to randomized eye, 4 times per day for 6 months
5% sodium chloride eye drop to randomized eye, 4 times per day for 6 months
0.18% sodium hyaluronate) eye drop to randomized eye
Experimental Drug,No Intervention No treatment
Ripasudil,control
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with corneal dystrophy stage 1 or stage 2 2. Older than 18 years old.
Exclusion criteria
Exclusion criteria: 1. Patients with eye inflammation or infectious eye inflammation or have had a viral infection of the cornea. 2. Patients who are pregnant or plan to become pregnant within 1 year or breastfeeding. 3. Patients who have had a corneal transplant before.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Central corneal thickness At first visit, 1 month, 3 months and 6 months after start drug Compare central corneal thickness by Anterior Segment Optical Coherence Tomography | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of endothelial cell and endothelial cell morphology At first visit, 1 month, 3 months and 6 months after start drug Compare Number of endothelial cell and endothelial cell morphology by ConfoScan4 confocal microscope | — |
Countries
Thailand
Contacts
Public ContactWipawee Booranapong
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed