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Comparing Local Anesthetic Efficacy between Lidocaine and Mepivacaine in Healthy Young Adults: A Double-blind Clinical Pilot Study

Comparing Local Anesthetic Efficacy between Lidocaine and Mepivacaine in Healthy Young Adults: A Double-blind Clinical Pilot Study

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250106002
Enrollment
250
Registered
2025-01-06
Start date
2025-02-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

To compare onset and duration of action in local anesthesia with epinephrine 1:100,000 between 2% Lidocaine and 2% Mepivacaine Dentistry

Interventions

The participants received standard injections of 2% lidocaine, with 1:100,000 epinephrine, targeting the Inferior Alveolar Nerve block. These injections were administered using either an aspirating or
Experimental Drug,Experimental Drug
Lidocaine,Mepivacaine

Sponsors

Faculty of Dentistry, Chulalongkorn University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
19 Years to 21 Years

Inclusion criteria

Inclusion criteria: 1. Individuals aged between 19 and 21 years, currently junior dental students engaged in practicing inferior alveolar nerve block, on one another as part of the Professional Development course controlled by maxillofacial surgeons. 2. Every participant had a minimum of two sound lower teeth including the first premolar tooth and the first molar tooth. These teeth were free from bridge, crown, severe caries damage, extensive restoration, advanced periodontal disease, history of trauma, or sensitivity guaranteed by maxillofacial surgeon. 3. Participants were required to report no current pain, be in good health, and not be taking any medication that might affect their perception of pain, as determined through verbal questioning. 4. the outcome measures would encompass at least one of the following: the success of anesthesia, the speed of onset of anesthesia, the duration of anesthesia, and any adverse effects.

Exclusion criteria

Exclusion criteria: 1. Individuals with cardiac disease or other systemic medical issues that impede the administration of local anesthesia. 2. Patients who were prescribed premedication drugs that could potentially impact the assessment before administering anesthesia. 3. Participants with an infection or acute inflammation at the injection site, which reduce the effectiveness of anesthesia or having pain in other teeth. 4. Participants with anatomic variations that can impact an IAN block, such as trismus, bifid mandibular canals, micrognathia, etc. 5. Participants who lack anesthesia will be excluded.

Design outcomes

Primary

MeasureTime frame
The study assessed the effectiveness of different types of local anesthesia in terms of success, onset, duration of action, and adverse effects for IAN block injections. 4 hr and 24 hr The onset of anesthesia was tracked using a digital timer and tested with 3-0 Nylon monofilament suture material for the light touch sensation test.

Secondary

MeasureTime frame
N/A N/A N/A

Countries

Thailand

Contacts

Public ContactSappasith Panya

Faculty of dentistry, Chulalongkorn university

Sappasith.p@chula.ac.th0638635995

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026