Bilateral total knee arthroplasty in primary osteoarthritis of both knees Bilateral total knee arthroplasty , Dexamethasone, Post-operative pain control, Primary osteoarthritis of knee
Conditions
Interventions
Dexamethasone 8 mg at intra-operation and 24 hours post-operation,Dexamethasone 16 mg at intra-operation and 24 hours post-operation
Active Comparator Drug,Experimental Drug
Intermediate dose dexamethasone,High dose dexamethasone
Sponsors
Buddhachinaraj Phitsanulok Hospital, Thailand
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patient undergoing bilateral TKA due to osteoarthritis of both knees 2.Age between 55-85 year olds 3.Weight between 50-90 kilograms 4.Abel to undergo spinal anesthesia for pain control during surgery 5.Assessed as ASA classification level 1-2 6.Willing to participate in research study with signed consent 7.Able to communicate read and write in Thai
Exclusion criteria
Exclusion criteria: 1.Use of corticosteroids within the past 3 months 2.Used of immunosuppressant drugs with in the past 3 months 3.Use of strong opioids within the past 7 days 4.Diagnosed with Diabetes mellitus 5.Suspected or diagnosed infectious disease 6.History of allergies to dexamethasone, opioids, tranexamic acid, paracetamol, omeprazole or lorazepam 7.History of gastric ulcer, severe heart disease, liver failure or renal failure 8.Unable to cooperate effectively 9.Participant decline or request to withdraw from this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain Post operative at 8h, 16h, 24h, 48h, 72h Visual analog scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Range of motion knee Post operative at 24h , 48h, 72h Degree,Knee circumference Post operative at 24h , 48h, 72h Centimeter,Blood glucose Post operative at 24h , 48h, 72h Blood glucose level,Time up and go Post operative at 72h Second,Morphine consumption Post operative at 24h , 48h, 72h Miligram | — |
Countries
Thailand
Contacts
Public ContactKatawut Kumplean
Buddhachinaraj Phitsanulok Hospital, Thailand
Outcome results
None listed