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The impact of Nefopam's on opioid comsumption in fullhouse endoscopic sinus surgery : A prospective randomized controlled trial

The impact of Nefopam's on opioid consumption in Fullhouse endoscopic sinus surgery : A prospective randomized controlled trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20241231003
Enrollment
100
Registered
2024-12-31
Start date
2025-01-06
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

To assess nefopam&#039

Interventions

nefopam 20 mg in saline 98 ml,saline 100 ml
Experimental Drug,Placebo Comparator No treatment
nefopam,control

Sponsors

Rachadapisek somposh funding
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged 18 and over 2. undergoing Fullhouse sinus surgery

Exclusion criteria

Exclusion criteria: 1. patients with chronic pain disease 2. patients with prior analgesia use 3. patients who concurrent medication are SSRI, SNRI, or MAOIs. 4. patients with acute angle closure glaucoma 5. patients at risk of acute urinary retention 6. epilepsy 7. patients with kidney and liver disease 8. allergy to study drug 9. pregnancy or lactation 10. patients with significant cardiac arrhythmia e.g. atrail fibrillation 11. patients with palpitation

Design outcomes

Primary

MeasureTime frame
opioid consumption 24 hour postoperative microgram of fentanyl use—

Secondary

MeasureTime frame
Numerical pain score from 2 hour - 24 hour postoperative score 0-10—

Countries

Thailand

Contacts

Public ContactSudapree Sorasuchart

King Chulalongkorn memorial hospital

sudapree.s@chula.ac.th0801546964

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026