Effect of toothpaste containing postbiotics on oral microbiome in volunteer

Effect of toothpaste containing postbiotics on oral microbiome in volunteers undergoing fixed orthodontic treatment

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20241226001

Enrollment

Registered

2024-12-26

Start date

2025-01-20

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subjects with orthodontic treatment have imbalance oral microbiome Postbiotics, Oral, Microbiome

Interventions

Tested group 15 subjects receive postbiotic toothpaste twice/day for 30 days in the morning and before bed. Collect the saliva samples before and after intervention, and analysis of oral microbiome.,C

Experimental Other,Active Comparator No treatment

Tested group,Control group

Eligibility

Sex/Gender

All

Age

18 Years to 25 Years

Inclusion criteria

Inclusion criteria: 1. subjects have healthy conditions no systemic diseases, 2. undergoing orthodontic treatment

Exclusion criteria

Exclusion criteria: 1. having severe periodontitis, 2. having systemic diseases, 3. taking antibiotics within 12 weeks, 4. having postbiotic toothpaste regularly

Design outcomes

Primary

Measure	Time frame
Bacterial pathogens 4 weeks software analysis	—

Secondary

Measure	Time frame
oral microbiome 4 weeks software analysis	—

Countries

Thailand

Contacts

Public ContactRawee Teanpaisan

Prince of Songkla University

rawee.t@psu.ac.th0896555836

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026