Correlation between factors associated with skeletal relapse following surgical correction of skeletal Class III malocclusion by surgery-first orthognathic approach

Correlation between factors associated with skeletal relapse following surgical correction of skeletal Class Il malocclusion by surgery-first orthognathic approach

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20241225003

Enrollment

Registered

2024-12-25

Start date

2024-12-12

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Class III malocclusion Surgery-first approach SFA Relapse Orthognathic surgery Skeletal Class III

Interventions

Pre-surgical orthodontic treatment performs before orthognathic surgery.,Orthognathic jaw surgery at the beginning of treatment without pre-surgical orthodontic treatment.

Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery

Conventional approach,Surgery-first approach

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Surgery-first group 1.Thai skeletal Class III deformity (ANB angle less than -4 degree) 2.Patients who will be received combined surgical and orthodontics treatment with surgery-first technique plan 3.Fully dentate patients (except for third molars and premolars extraction for orthodontic purpose) Conventional group 1.Thai skeletal Class III deformity (ANB angle less than -4 degree) 2.Patients who are undergoing combined surgical and orthodontics treatment with conventional technique plan 3.Fully dentate patients (except for third molars and premolars extraction for orthodontic purpose)

Exclusion criteria

Exclusion criteria: 1. Patients with congenital cranial malformations or syndromes 2. Patients who have orthognathic surgery plan with multi-segmented osteotomy 3. Patients who have significant facial asymmetry (menton deviation more than 4 mm.) 4. Patients who are allergic to peanuts 5. Patients who have symptomatic TMD according to the assessment protocol of Schiffman et. al 6. Patients who are undergoing downward maxillary surgery more than 3 mm. 7. Patients who are not willing to attend this study

Design outcomes

Primary

Measure	Time frame
Amount of skeletal changes in vertical and horizontal direction prior to surgery (T0), 2 weeks post-operative (T1), 6 months post-operative (T2), and 1 year post-operative (T3). Millimeter/ Cephalometric analysis	—

Secondary

Measure	Time frame
N/A N/A N/A	—

Countries

Thailand

Contacts

Public ContactThanit Charoenrat

Faculty of Dentistry, Chulalongkorn University

thanit.ch@chula.ac.th0221889302

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026