New bone formation in grafted site Post-operation pain and swelling rh-BMP Bone graft Ridge preservation
Conditions
Interventions
After impacted tooth removals, the bare tooth sockets in the test group will be filled with Ossicure Bone Graft. Then the flap will be sutured using primary intention technique.,After impacted tooth r
Test material,Positive control,Negative contrl
Sponsors
National Science and Technology Development Agency
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The healthy adult patients (ASA I, II) over 18 years old of age undergo at least one of third molar surgical removal. 2. The patients have at least one of third molar impacted tooth. The tooth must be clinical missing or can be provided primary surgical wound closure after tooth removal.
Exclusion criteria
Exclusion criteria: 1. The site of impacted teeth showing signs of inflammation 2. The teeth which locate obviously involving the maxillary sinus or inferior alveolar nerve 3. The subjects who refuse to participate in the study 4. The subjects who cannot come for follow-up and taking CBCT after treatment 5. The smoking subjects 6. The subjects with the history of allergy to hypersensitivity to recombinant human Bone Morphogenetic Protein-2 and bovine Type I collagen 7. The subjects with the history of exposure to the medications which could interfere the bone repair process, for example, Bisphosphonates, RANKL inhibitors etc. and the subjects with history of radiation in head and neck area. 8. The subjects with the uncontrolled systemic diseases which could interfere the wound healing process, for example, Diabetes Miletus, Osteoporosis etc. and the subjects with the contraindicated conditions for dental treatments, for example, uncontrolled hypertension, bleeding tendency etc.. 9. Pregnant or lactating females
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| New bone formation 2 weeks, 2 months and 4 months Grey value in cone beam computed tomography | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain 0hour, 6hour, 1 day, 2 day, 3 day ,4 day, 5 day, 6 day, 7 day 0-10 Visual analog scale,Swelling 0hour, 6hour, 1 day, 2 day, 3 day ,4 day, 5 day, 6 day, 7 day 0-10 Visual analog scale | — |
Countries
Thailand
Contacts
Public ContactSirimanas Jiaranuchart
Chulalongkorn university
Outcome results
None listed