Intravenous tranexamic acid can reduce intraoperative blood loss during craniotomy for meningioma resection Intraoperative blood loss, Craniotomy for meningioma resection, Tranexamic acid
Conditions
Interventions
Intraoperative, The tranexamic acid was administered intravenously as a 10 mg/kg bolus before surgical incision, then continue infusion at 1 mg/kg/hr along the surgical procedure. Limit tranexamic aci
Experimental Drug,Placebo Comparator Drug
TXA,Placebo
Sponsors
Office of research and development, Phramongkutklao hospital and Phramongkutklao college of medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patient scheduled for elective craniotomy for meningioma resection 2.ASA physical status 1-2
Exclusion criteria
Exclusion criteria: 1.Patient refusal 2.Preoperative embolization 3.History of tranexamic acid allergy 4.History of bleeding disorder or thrombotic disease 5.History of myocardial ischemia or ischemic stroke 6.Pregnancy 7.History of seizures 8.Serum creatinine more than 1.2mg/dl
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood loss Intraoperatively Volume of blood in the surgical suction collection, excluding the fluid resulting from surgical field irritation.,Rate of blood transfusions Intraoperatively Quantity of packed red cell (PRC) unit transfusions | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital length of stay Hospital admission Patient medical record,ICU length of stay Hospital admission Patient medical record,Time for mechanical ventilator Hospital admissions Patient medical record,7 days mortality rate 7 days after operation Patient medical record | — |
Countries
Thailand
Contacts
Public ContactGrit watanaboonyongcharoen
Phramongkutklao hospital
Outcome results
None listed