all patients age 18 years or more, diagnosed with abnormal lung mass who required a transbronchial lung biopsy Transbronchial lung biopsy, Bleeding, Tranexamic acid, Adrenaline, Wedge pressure
Conditions
Interventions
Bronchoscope began with an airway inspection, followed by bronchoalveolar lavage sampling. In tranexamic group, tranexamic acid 50mg/10ml was diluted with normal saline up to 20ml, prepared by the per
Experimental Drug,Placebo Comparator Other
tranexamic acid group,control group
Sponsors
Research of Maharat Nakhonratchasima Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. age at 18 years or more, 2. abnormal lung mass required transbronchial lung biopsy, 3. platelet count equal or greater than 100,000, 4. INR equal or less than 1.2
Exclusion criteria
Exclusion criteria: 1. respiratory failure or impending respiratory failure, 2. unstable hemodynamic status or those receiving inotropic drugs, 3. endobronchial lesion, 4. active hemoptysis, 5. using antiplatelet or anticoagulant therapy within 7 days prior transbronchial lung biopsy, 6. using oral contraceptives or hormonal replacement therapy, 7. pregnancy or breastfeeding, 8. history of bleeding predisposition, 9. venous-thromboembolism, 10. cardiovascular disease, 11. chronic liver disease, 12. chronic kidney disease (GFR < 45 ml/min), 13. urinary tract stones, 14. history of allergy to tranexamic acid
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bleeding severity during procedure the Nashville Bleeding Scale | — |
Secondary
| Measure | Time frame |
|---|---|
| interventions to control bleeding during procedure bronchoscopist report,number of biopsy post-procedure bronchoscopist report,procedure duration post-procedure medical record time in and time out,complication up to 2week of follow up patient report, medical record | — |
Countries
Thailand
Contacts
Public ContactSuphanan Autto
Maharat Nakhonratchasima Hospital
Outcome results
None listed