A Randomized Controlled Trial of colistin combined with sulbactam versus colistin combined with sulbactam and high dose tigecycline in treatment of carbapenems resistant Acinetobacter baumanii(CRAB) pneumonia

A Randomized Controlled Trial of colistin combined with sulbactam versus colistin combined with sulbactam and high dose tigecycline in treatment of carbapenems resistant Acinetobacter baumannii (CRAB) pneumonia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20241218002

Enrollment

130

Registered

2024-12-18

Start date

2024-12-25

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Extensively drug resistance A. baumannii pneumonia XDR A. baumannii, colistin, sulbactam, high dose tigecycline

Interventions

Give colistin combined with sulbactam and high dose tigecycline,Give colistin combined with sulbactam

Experimental Drug,Experimental Drug

Colistin combined with sulbactam and high dose tigecycline,Colistin combined with sulbactam

Eligibility

Sex/Gender

All

Age

20 Years to 100 Years

Inclusion criteria

Inclusion criteria: A. baumannii XDR pneumonia patient Age 20 or over 20 years old

Exclusion criteria

Exclusion criteria: -Sputum culture show mixed organism -Concurrent or coinfection with other organism -Not recieved colistin for empirical treatment -Recieve colistin >6 calendar days before date of collected sputum -Allergy to colistin or sulbactam -Previous participated in this trial within 14 days -Pregnancy

Design outcomes

Primary

Measure	Time frame
mortality 7 and 28 days mortality rate	—

Secondary

Measure	Time frame
Factor associated mortality 28 days ICU day, ventilator day, adverse event, length of ICU stay or mechanical ventilator use, adverse drug events until discharged from ICU, off mechanical ventilator, complete treatment	—

Countries

Thailand

Contacts

Public ContactTanyanop Techasupaboon

Phramongkutklao hospital

techasupaboon@gmail.com0864659695

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026