Gene expression analysis of RANKL and OPG as biomarkers for remodeling of autogenous dentin graft compared with autogenous bone in post-extraction sites: A novel randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20241215010

Enrollment

Registered

2024-12-15

Start date

2025-02-10

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

By measuring RANKL and OPG levels in both palatal bone and dentin grafts, we can gain insights into how these graft materials may influence the osteogenic process and their effectiveness in socket preservation. RANKL, OPG, palatal graft, dentin graft, ridge preservation

Interventions

In group I, ADG will be obtained from the extracted tooth to preserve the socket after mixing it with the patient&#039

s own blood. After that, socket debridement with passive graft filling, absorbable gelatine sponge (Gelfoam) placement, and figure of 8 suture using 5/0 nylon type over the grafted socket will be acco

Experimental Procedure/Surgery,Active Comparator Procedure/Surgery

Autogenous dentin graft (ADG),Autogenous bone graft (ABG)

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Any patient who needs dental extraction for maxillary 1st premolar (1P) and 2nd premolar (2P) will be included.

Exclusion criteria

Exclusion criteria: Patients with compromised health condition and/or systemic disease involving the bone, long span edentulous ridge (tooth standing alone), age below 18y, history of cleft palate, oro-antral communication at the time of extraction, heavy smoking, previous radiation therapy, and traumatic extraction will be excluded from this study.

Design outcomes

Primary

Measure	Time frame
Receptor activator of NF-kB ligand (RANKL) Time of surgery (T0), after 4 months (T1) Concentrations (ng/ml) / Quantitative reverse transcription polymerase chain reaction (RT-qPCR),Osteoprotegerin (OPG) Time of surgery (T0), after 4 months (T1) Concentrations (ng/ml) / Quantitative reverse transcription polymerase chain reaction (RT-qPCR),RANKL/OPG Time of surgery (T0), after 4 months (T1) Ratio,Dimensional changes of the socket walls 4 months after surgery Millimeter (mm) / Radiograph (CBCT),Bone density 4 months after surgery Gray scale / Radiograph (CBCT)	—

Measure

Time frame

Receptor activator of NF-kB ligand (RANKL) Time of surgery (T0), after 4 months (T1) Concentrations (ng/ml) / Quantitative reverse transcription polymerase chain reaction (RT-qPCR),Osteoprotegerin (OPG) Time of surgery (T0), after 4 months (T1) Concentrations (ng/ml) / Quantitative reverse transcription polymerase chain reaction (RT-qPCR),RANKL/OPG Time of surgery (T0), after 4 months (T1) Ratio,Dimensional changes of the socket walls 4 months after surgery Millimeter (mm) / Radiograph (CBCT),Bone density 4 months after surgery Gray scale / Radiograph (CBCT)

—

Secondary

Measure	Time frame
Surgical complications At the time of operation Clinically,Post-operative morbidities After surgery, at 4 months Clinical evaluation	—

Countries

Iraq

Contacts

Public ContactFiras Jamil

College of Dentistry, University of Baghdad

dr.firasjamil@gmail.com7901892291

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026