Patients with anti-interferon-gamma autoantibody-associated adult-onset immunodeficiency syndrome developed new infections or re-infections despite taking proper antibiotics. Various immunosuppressive drugs have been studied to treat patients with autoantibody deficiency to interferon gamma and found to reduce antibody production. A research project was proposed to study the treatment of anti-interferon-gamma autoantibody-associated adult-onset immunodeficiency syndrome with azathioprine. Azath
Conditions
Interventions
Participants who passed the eligible criteria will receive azathioprine at dose of 50 mg/day and they will be appointed to visit the clinic to follow up clinical and blood testing parameter at week 2,
Experimental Drug
Azathioprine
Sponsors
Siriraj Hospital
Eligibility
Sex/Gender
All
Age
21 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 21-70 years old 2. Non-pregnant woman 3. Detection of anti-IFNG auto-Ab by ELISA method or other standard method 4. Anti-HIV negative 5. A history of opportunistic infection at least 1 episode with received antimicrobial treatment for at least 1 month
Exclusion criteria
Exclusion criteria: 1. Pregnant or breast-feeding woman 2. ANC < 1,500 or Platelet count < 100,000 or Hb < 8 g/dL 3. AST or ALT > 3x UNL 4. Renal impairment (GFR < 10 ml/min or hemodialysis dependent) 5. Known history or suspected allergic to azathioprine 6. Other immunodeficiency conditions, such as receiving steroids, other immunosuppressive drugs, or active cancer which receiving cytotoxic chemotherapy agent. 7. Using allopurinol, febuxostat and upadacitinib in current medication 8. Other medical conditions that may adversely affect the safety of the participants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Anti-IFNG auto-Ab levels 24 week Optical density (O.D.) and arbitrary unit (A.U.) | — |
Secondary
| Measure | Time frame |
|---|---|
| The Anti-IFNG auto-Ab levels 48 week Optical density (O.D.) and arbitrary unit (A.U.),The occurrence of active disease 48 week Number of occurence,The incidence of recurrent infections 48 week Number of incidence,Serious adverse event 48 week Number of event | — |
Countries
Thailand
Contacts
Public ContactNasikarn Angkasekwinai
Faculty of Medicine, Siriraj Hospital
Outcome results
None listed