Effects of Inspiratory Muscle Training on Dyspnea, Respiratory Muscle Strength, and Quality of Life in Patients After Prolonged Mechanical Ventilation: A Randomized Controlled Trial

Combine EEffects of Inspiratory Muscle Training on Dyspnea, Respiratory Muscle Strength, and Quality of Life in Patients After Prolonged Mechanical Ventilation: A Randomized Controlled Trialffects of Robotic Assisted Gait Training (RAGT) with Trans-cranial Magnetic Stimulation (TMS) on Gait metrics and Balance in Stroke Patients: A Randomized Control Trial.

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20241209001

Enrollment

Registered

2024-12-09

Start date

2025-01-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyspnea Respiratory Muscle Strength Quality of Life in Patients ICU Patients Inspiratory muscle training Mechanical ventilation Weaning Dyspnea Quality of life Respiratory muscle strength Diaphragm ultrasound Critical care rehabilitation

Interventions

Lokomot Robotic-assisted gait training with walking speed ranging from 1.5 - 1.8 km/hr. Session time is 40 minutes with 5 minutes to donn and doff.,TMS Low frequency of 0.1- 1 HZ. Intensity 80% of RMT

Experimental Device,Active Comparator Device,Active Comparator Other

Robotic Assisted Gait Training (RAGT) ,Low-Frequency Transcranial Magnetic Stimulation (LF-rTMS),Conventional Physical therapy

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age 18 years or older 2. Weaned off mechanical ventilation successfully in the last 24 hours 3. Stable vital indicators (such as blood pressure, heart rate, oxygen saturation, and respiratory rate, that are within normal clinical ranges make it safe to use the IMT technique) 4. Absence of ongoing requirement for vasopressor or inotropic support, or hemodynamic instability (this standard was derived from American Thoracic Society/European Respiratory Society recommendations, which prohibit IMT in individuals with hemodynamic instability) 5. No serious respiratory or cardiovascular problems that could make it unsafe to use IMT [such as uncontrolled asthma, severe chronic obstructive pulmonary disease (COPD), a recent heart attack (within the last four weeks), or severe pulmonary hypertension], 6. Sufficient cognitive function and communication skills to comprehend and adhere to the IMT protocol. 7. Patients had to be able to follow verbal instructions and show the right technique throughout training sessions. 8. No recent history of neuromuscular disorders that could impact the function of the respiratory muscles (such as myasthenia gravis, Guillain-Barre syndrome, or other syndromes that affect the peripheral nerves or the neuromuscular junction).

Exclusion criteria

Exclusion criteria: 1. Presence of a tracheostomy (as the modified respiratory mechanics in these individuals may affect both the implementation and results of IMT). 2. Any additional medical ailment or clinical situation deemed by the investigator to obstruct safe research participation or adherence to the protocol.

Design outcomes

Primary

Measure	Time frame
Maximum Inspiratory Pressure (MIP) 8 week digital manometer with a mouthpiece ,Dyspnea Assessment 8 Week modified Borg scale	—

Secondary

Measure	Time frame
Diaphragm Excursion 8 week Ultrasound,Diaphragm Diaphragm Thickness 8 Week Ultrasound,Quality of Life 8 Week 36-Item Short Form Health Survey (SF-36)	—

Countries

China

Contacts

Public ContactWarda Khan

Chongqing Medical University

i23454654@qq.com18723443204

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026