Patient with hypertrophic scars and keloid hypertrophic scars,keloid
Conditions
Interventions
Intralesional triamcinolone acetonide 40 mg/ml Administered drug in the upper dermis until slight blanching.maximum drug is triamcinolone acetonide 40 mg ,4 weeks interval for 3 session
,Intralesiona
Intralesional triamcinolone acetonide,Intralesional triamcinolone acetonide with hyaluronidase ,Intralesional hyaluronidase
Sponsors
Institute Srinakharinwirot University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Patient diagnosed with Keloid and hypertrophic scar 2.Measuring more than 3 mm. In height 3.Able to follow up examination 4.Participate in the project voluntarily and sign the consent
Exclusion criteria
Exclusion criteria: 1.Presentation of Other dermatology disease e.g.skin infection, Dermatitis ,psoriasis 2.Patients with underlying disease include Diabetes mellitus,Hypertension,Active peptic ulcer,osteroporosis,glaucoma or adrenal insufficiency 3.Patients with Immunocompromised host or liver failure or kidney failure 4.Patients prone to adrenal insufficiency by screening quesionaire 5.History steroid drugs useage in the form of injection or topical drugs within 3 months before the start of the study. 6. keloids and hypertrophic scar were treated in different ways within 3 months prior to the start of the study 7.History of allergy to triamcinolone acetonide or hyaluronidase or the ingredients of the injection such as Benzyl alcohol, Polysorbate 80, Carmellose sodium 8.History of allergy to steroid drug 9.History of allergy to bee, wasp or hornet 10.Pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vancouver scar score at 12 weeks after end of the intervention Vancouver scar score | — |
Secondary
| Measure | Time frame |
|---|---|
| Height at 12 weeks after end of the intervention vernier caliper,Erythema index at 12 weeks after end of the intervention Mexameter,melanin index at 12 weeks after end of the intervention Mexameter,Pliability at 12 weeks after end of the intervention cutometer ,Patient and doctor satisfaction at 12 weeks after end of the intervention Visual analog scale,Triamcinolone level at 12 weeks after end of the intervention Triamcinolone level,Morning cortisol level at 12 weeks after end of the intervention Morning cortisol level | — |
Countries
Thailand
Contacts
Public Contactsalinee rojhirunsakool
Faculty of Medicine,Srinakharinwirot University
Outcome results
None listed