intrathecal morphine-induced nausea and vomiting in patients undergoing cesarean section intrathecal morphine-induced nausea and vomiting, cesarean section
Conditions
Interventions
nalbuphine 4 mg IV ,NSS 4 ml IV
Active Comparator Drug,Placebo Comparator No treatment
nalbuphine ,placebo
Sponsors
thammasat University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Elective cesarean section under spinal anesthesia 2. older than 18 years old
Exclusion criteria
Exclusion criteria: 1. Patients with known allergy to research drugs such as nalbuphine, bupivacaine or morphine 2. Medical complications eg heart diseases, diabetes, hypertension, renal or hepatic disease, obesity >=100 kilograms 3. Obstetrical complications eg twins or multiple gestation, pre-eclampsia, IUGR(intra-uterine growth retardation), placenta previa 4. History of postoperative nausea and vomiting (PONV), motion sickness or passive smoker 5. Patient with known history of drug abuse 6. Unwilling to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| event rate of nausea and vomiting postoperative 1,6,24 hr event rate | — |
Secondary
| Measure | Time frame |
|---|---|
| severity of nausea postoperative 1,6,24 hr nausea and vomiting score 0-3,severity of pruritus postoperative 1,6,24 hr pruritus score 0-3,sedation score postoperative 1,6,24 hr sedation score 0-3 ,pain score postoperative 6,24 hr Numeric pain score | — |
Countries
Thailand
Contacts
Public ContactPreeyaphan Arunakul
Department of Anesthesiology, Faculty of Medicine, Thammasat University
Outcome results
None listed