it more difficult for patients to schedule follow-up appointments and receive treatment. However, it is essential for these cancer patients to continuously seek care at hospitals. Biliary drainage is necessary to administer chemotherapy and help alleviate discomfort from obstructive bile duct conditions. EUS-guided hepaticogastrostomy (EUS-HGS), endoscopic retrograde cholangiopancreatography (ERCP), malignant distal biliary obstruction (MDBO)
Conditions
Interventions
Endoscopic Retrograde CholangioPancreatography (ERCP) to place a stent through the narrowed area. This is because ERCP has been studied more extensively. Endoscopic ultrasonography-guided biliary drai
Experimental Procedure/Surgery,Experimental Procedure/Surgery
endoscopic retrograde cholangiopancreatography (ERCP),EUS-guided hepaticogastrostomy (EUS-HGS)
Sponsors
Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology, Division of Gastroenterology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients aged 18-75 years who have signed the informed consent form to participate in the research. Patients with unresectable cancer causing distal bile duct obstruction requiring, suitable for and would undergo endoscopic biliary drainage. Patients in a reasonably good physical condition (ECOG less than 2). Patients with life expectancy longer than 6 months. Patients with viable liver volume more than 80%. Patients without preceding hepatectomy or atrophic liver. Patients without cirrhosis child B or C. Patients without significant ascites that might preclude EUS-HGS.
Exclusion criteria
Exclusion criteria: Patients with hilar bile duct obstruction. Patients with abnormal blood clotting or platelet function that cannot be corrected (INR < 1.5 or platelet count <50,000). Pregnant patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrent biliary obstruction (RBO) 6 months Quality of life (EORTC QLQ-30) | — |
Secondary
| Measure | Time frame |
|---|---|
| Technical success: 6 months Quality of life (EORTC QLQ-30),Clinical success 6 months Quality of life (EORTC QLQ-30),Clinical success 6 month Quality of life (EORTC QLQ-30) | — |
Countries
Thailand
Contacts
Public ContactPradermchai Kongkam
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed