Moderate to severe chronic obstructive pulmonary disease (COPD) COPD, tDCS, resistance training
Conditions
Interventions
In the resistance exercise with the sham-tDCS group, subjects will receive anodal-tDCS 2 mA
stimulation for 20 minutes before exercise, but the tDCS device will power off after stimulation 30 seconds
Sham Comparator Other,Experimental Other
Sham-tDCS with resistance training,tDCS with resistance training
Sponsors
Research Fund for Supporting Lecturer to Admit High Potential Student to Study and Research on His Expert Program Year 2021 (641JH214)
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Post-bronchodilator of FEV1/FVC < 70% 2. Post-bronchodilator of FEV1 30-80% of predicted value 3. Age 40-85 years 4. Non-regular exercise (<3times/week and <30 min/day)
Exclusion criteria
Exclusion criteria: 1. Other respiratory diseases such as asthma, bronchiectasis, pulmonary hypertension 2. Acute exacerbation within a month before starting these studies 3. Congestive heart failure, angina pectoris, and third-degree A-V block 4. The presence of orthopedic or neuromuscular conditions interfering with the ability to perform resistance exercises such as herniated disc, lumbar stenosis, and muscle weakness 5. No metallic implants near electrodes and no use of pacemaker 6. No history of neurological disorders such as stroke
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exercise capacity Pre-test at before intervention, Mid-test at after intervention for 4 weeks, Post-test at after intervention for 8 weeks Six-minutes walk test | — |
Secondary
| Measure | Time frame |
|---|---|
| Respiratory muscle strength Pre-test at before intervention, Mid-test at after intervention for 4 weeks, Post-test at after intervention for 8 weeks Maximum inspiratory and expiratory pressure,Lung function Pre-test at before intervention, Mid-test at after intervention for 4 weeks, Post-test at after intervention for 8 weeks Spirometry test,Physical performance Pre-test at before intervention, Mid-test at after intervention for 4 weeks, Post-test at after intervention for 8 weeks Timed Up and Go test,Physical performance Pre-test at before intervention, Mid-test at after intervention for 4 weeks, Post-test at after intervention for 8 weeks Single leg stance test,Physical performance Pre-test at before intervention, Mid-test at after intervention for 4 weeks, Post-test at after intervention for 8 weeks 4-meter gait speed test,Physical performance Pre-test at before intervention, Mid-test at after intervention for 4 weeks, Post-test at after intervention for 8 weeks Five times sit to stand test,Physical performance Pre-test at before intervention, Mid-test at after intervention for 4 weeks, Post-test at after intervention for 8 weeks Hand grip strength test,Systemic oxidative stress Pre-test at before intervention, Mid-test at after intervention for 4 weeks, Post-test at after intervention for 8 weeks Oxidative stress marker,Systemic inflammation Pre-test at before intervention, Mid-test at after intervention for 4 weeks, Post-test at after intervention for 8 weeks Inflammatory cytokines marker | — |
Countries
Thailand
Contacts
Public ContactChalermkiat Sawasdee
Faculty of Medicine, Khon Kaen University
Outcome results
None listed