nasal symptoms of allergic patients when pre and post recieved probiotics allergic rhinitis,rhinitis,probiotics
Conditions
Interventions
Probiotics capsule include Bifidobacterium animalis TA1, Lactobacillus paracasei MSMC391 and Lactobacillus reuteri TF314 500 mg oral dialy dose for 8 weeks
,Placebo capsule 500 mg oral dialy dose for
Sponsors
HRH princess Maha Chakri Siridhorn Medical center
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-60 years 2. Confirm diagnosis of allergic rhinitis 3.AR type : mild persitent,moderate to severe persitent and moderate to severe intermittent AR
Exclusion criteria
Exclusion criteria: 1.non allergic rhinitis 2.chronic rhinosinusitis with or without nasal polyp 3.nasal mass or nasal cancer or sinus cancer 4.petient with adverse effect of probiotics 5.pregnancy or lactating woman 6.caution with probiotic e.g.immunocompromise, prosthetic heart valves, impaired intestine function, central venous catheter, jejunostomy, broad-spectrum antimicrobials and poorly control diabetes mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nasal symptoms score of allergic pateints compare pre and post recieved probiotics 8 weeks Visual analogue scale (VAS) , Total nasal symptom score (TNSS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison the quality of life ,Blood test and side effect of probiotics in treatment allergic rhinitis 8 weeks Using rhinoconjunctivitis quality of life questionaire (RQLO) and blood enzymatics (total IgE,eosinophil count ,IL4,IL5,TFNGand TH1:Th2 ratio) | — |
Countries
Thailand
Contacts
Public ContactPanuwat Wongwattana
Srinakharinwirot university
Outcome results
None listed