Comparison of single dose intra-articular platelet-rich plasma and corticosteroid in patients with bilateral osteoarthritis of the knee: A double-blinded randomized controlled trial

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20241110012

Enrollment

Registered

2024-11-10

Start date

2024-11-25

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Symptomatic bilateral moderate OA of the knee (Kellgren and Lawrence grade II to III) Platelet-rich plasma, PRP, Corticosteroids, Knee osteoarthritis, RCT, Kellgren-Lawrence grade II-III

Interventions

PRP was prepared by a physician (research or co-researcher) with RegenLab training under a closed-circuit system using the RegenKit BCT (Regen Lab, Switzerland). 10mL of the patient&#039

s blood was taken from an antecubital vein under aseptic technique by a registered nurse. Bedside preparation of the PRP was made according to the manufacturer&#039

s guidelines using the Regen Lab PRP centrifuge (1500 relative centrifugal force for 5 minutes) which yielded 5-6 mL of leukocyte-poor PRP with a standardized composition and will be injected immediat

s recommendation.,1mL of 40mg/mL of Triamcinolone was mixed up to 6mL with 1% lidocaine and injected into the patient&#039

s contralateral knee.

Active Comparator Drug,Active Comparator Drug

Platelet rich plasma,Corticosteroid

Eligibility

Sex/Gender

All

Age

40 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged 40 or more years 2. Symptomatic primary bilateral osteoarthritis of the knee 3. Clinical and radiologic confirmation of knee osteoarthritis (Kellgren and Lawrence grade II to III) 4. BMI ranging from 18.5 to less than 30

Exclusion criteria

Exclusion criteria: - Post-traumatic knee OA - Pregnancy or breastfeeding - Previous knee interventions within three months (such as hyaluronic or steroid injections) - Previous femur or tibia fracture - Documented history of corticosteroid allergy - Previous NSAIDs treatment (within 10 days prior to the intervention) - Ongoing oncological, endocrine, autoimmune, infectious, or hematological disease

Design outcomes

Primary

Measure	Time frame
Knee and Osteoarthritis Outcome score (KOOS) (pain and symptom sub-scores) Two weeks, one month and three months post-injection of PRP and CCS change in KOOS scores,Visual analog scale (VAS) Two weeks, one month and three months post-injection of PRP and CCS change in BAS scores	—

Secondary

Measure	Time frame
Use of rescue medication Daily Record form for frequency of rescue medication use,Adverse effects Daily Record form for adverse effects encountered	—

Countries

Thailand

Contacts

Public ContactVarah Yuenyongviwat

Prince of Songkla Univeristy

Varah.y@psu.ac.th074451601

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026