Gram negative septicemia Gram negative septicemia, Rapid Antimicrobial Susceptibility Testing
Conditions
Interventions
standard treatment,The Clinical Microbiology Unit in the Laboratory Medicine Department at Srinagarind Hospital routinely performs direct disk diffusion testing directly from culture bottles when gram
s susceptibility to antibiotics such as meropenem, imipenem, ertapenem, ceftazidime-avibactam, sitafloxacin, fosfomycin, cefoperazone-sulbactam, ceftriaxone, ceftazidime, and ciprofloxacin. According
Laboratory Standards Institute (CLSI) guidelines from 2022, laboratories can perform direct disk diffusion testing from culture bottles specifically for Enterobacterales and Pseudomonas aeruginosa.
T
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patient was 18 years of age or older 2. Hemoculture: Gram negative bacilli at least 1 sample in 24 hours before enrollment
Exclusion criteria
Exclusion criteria: 1. Patient passed away in 24 hours after enrollment 2. Primary doctor rejected the advise of changing the antibiotics from infectious disease doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to optimal targeted antibiotic 72 hours Calculated as the time from detection of Gram-negative bacteria in the blood culture to the initiation of antibiotic therapy with the narrowest-spectrum, most effective agent | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality rate 28 days Mortality rate | — |
Countries
Thailand
Contacts
Public ContactPawarit Kulwongroj
Faculty of Medicine, Khon Kaen University
Outcome results
None listed