There are no standard recommendations for maintaining the effects of tocolytics. This is the first study to compare dosage of progesterone in the aspected of maintanance tocolytic effects. Hopefully, The result of this study may increase precentage of the term birth and improved neonatal outcome. - oral micronized progesterone. - preterm birth - neonatal outcome
Conditions
Interventions
200 mg per day of oral micronize progesterone, prescribe after complete acute tocolytic effect 48 hours until 36 week of gestation,600 mg per day of oral micronize progesterone, prescribe after comple
Experimental Drug,Active Comparator Drug
200 mg per day of oral micronize progesterone,600 mg per day of oral micronize progesterone
Sponsors
Thai Red Cross Society
Eligibility
Sex/Gender
Female
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Low risk with singleton pregnancy 2.Presented with preterm labor and responded to acute tocolysis treatment 3.Gestational age of 24 to 33+6 weeks 4.Cervical dilation less than 3 cm at the time of recruitment
Exclusion criteria
Exclusion criteria: 1.Have contraindication and inability to tolerate the side effects of micronized progesterone 2.Have risk factors for preterm labor (e.g., previous preterm birth, prior LEEP, polyhydramnios, bacterial vaginosis) 3.Progression to the active phase of labor or presence of ruptured membranes 4.Requirement for any tocolytic drugs after recruitment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Precent of term birth and the number of day prolongation period at the day of delivery record | — |
Secondary
| Measure | Time frame |
|---|---|
| Neonatal outcome (BBW, Apgar score, NICU admission) at the day of delivery record,Side effect of oral micronized progesterone every visit record | — |
Countries
Thailand
Contacts
Public ContactPitchaya Hotravareekarnjana
Thai red cross society
Outcome results
None listed