Patients with 2-3 stage Parkinson'
Conditions
Interventions
Eight participants in the CON group. No intervention with standard care.,Eight participants in the WALK group practiced walking exercise training for 15 min x 2 sets, (rest for 1 min between a set) at
s Disease Rating Scale (UPDRS): An evaluation of the severity of Parkinson'
s disease symptoms.
- Parkinson'
s Disease Quality of Life Questionnaire-8 (PDQ-8): A quality-of-life assessment for patients with Parkinson'
s disease.
2. The collect blood chemical variables to measure as follows: BDNF levels by drawing blood from the inner elbow (antecubital vein). And a fingerstick blood test to measure blood lactate le
Control Group (CON),Walking Group (WALK),Walking with Blood Flow Restriction Group (WBFR)
Sponsors
Faculty of Physical Education
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male and female with Parkinson's disease at least than 50 years old 2. Hoehn and Yahr staging between 2 and 3 3. Walk at least 10 meters without assistance 4. Risk assessment passed by a Neurologist
Exclusion criteria
Exclusion criteria: 1. Dementia, or previously diagnosed with anxiety or depressive disorders 2. TMSE assessment <23 scores 3. Denied participation in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain-derived neurotrophic factor baseline and after 8 weeks of training Human BDNF ELISA Kit | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive function baseline and after 8 weeks of training Thai Mental State Examination (TMSE) scores,Quality of life baseline and after 8 weeks of training Parkinson's Disease Quality of Life (PDQ-8) Questionnaire,Disease Severity baseline and after 8 weeks of training Unified Parkinson's Disease Rating Scale (UPDRS) ,Blood lactate before and after of acute experimental Lactate meter,Blood pressure baseline and after 8 weeks of training Blood pressure monitor,Body Composition (As follows: Body mass index, Body weight, Visceral fat, Body fat percentage, Basal metabolic rate, and Skeletal muscle mass percentage) baseline and after 8 weeks of training Body composition monitor,Calf Circumference baseline and after 8 weeks of training Body tape measure,Thigh Circumference baseline and after 8 weeks of traning Body tape measure,Functional performance (1); strength, movements, balance baseline and after 8 weeks of traning Five times sit-to-stand test ,Functional performance (2); stability, gait, stride length, sway baseline and after 8 weeks of training Time up and go test ,Functional performance (3); gait speed baseline and after 8 weeks of training 10-meter walk test ,Brachial-ankle pulse wave velocity baseline and after 8 weeks of training Pulse wave velocity machine,Flow-mediated dilation baseline and after 8 weeks of training Ultrasound portable machine and Popliteal analyzer for research program,Muscle oxygenation during walking exercise 30 minutes of acute experimental Near-infrared spectroscopy | — |
Countries
Thailand
Contacts
Public ContactKetsirin Kittipongphakorn
Srinakharinwirot University
Outcome results
None listed