Efficacy of topical intraarticular bupivacaine compared with periarticular bupivacaine in controlling pain after total knee arthroplasty: A randomized controlled non-inferiority trail.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20241012003

Enrollment

Registered

2024-10-12

Start date

2024-10-17

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing elective unilateral TKA topical intraarticular bupivacaine

Interventions

Post operative total knee arthroplasty, 0.5% bupivacaine 10 ml plus NSS 10 ml intraarticular injection with radivac drainage.,Intra operative total knee arthroplasty, 0.5% bupivacaine 10 ml plus NSS

Experimental Procedure/Surgery,Active Comparator Procedure/Surgery

topical intraarticular bupivacaine ,periarticular bupivacaine

Eligibility

Sex/Gender

All

Age

55 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Aged 55-80 years with ASA class of I-III scheduled to undergo primary unilateral elective TKA. 2. BMI 18-40 kg/m2. 3.Gave informed consent to participate. 4. No history of NSAIDs allergy. 5. No history of chronic opioid use disorders.

Exclusion criteria

Exclusion criteria: 1.Allergic to or contraindication for any of the study drugs. 2.Contraindication for neuraxial anesthesia and peripheral anesthesia. 3.Severe kidney or liver disease.

Design outcomes

Primary

Measure	Time frame
Post operative VAS score in 24 hours postoperative period hour	—

Secondary

Measure	Time frame
TIme to first analgesic request post operative perior hour	—

Countries

Thailand

Contacts

Public ContactAttanakan Kawpradist

Rayong Hospital

Attanakan@hotmail.com0865243639

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026