The comparison of transport mechanical ventilator and bag-valve ventilation during cardiopulmonary resuscitation in out-of-hospital cardiac arrest; A time independent-controlled trial study

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20241008007

Enrollment

Registered

2024-10-08

Start date

2024-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Out-of-hospital cardiac arrest patients aged 18 years and older, attended by the Ramathibodi Hospital Emergency Medical Operations Unit over a period of one year after research approval. Out-of-Hospital Cardiac Arrest Ventilation, Mechanical Bag-Valve-Mask Ventilation Return of Spontaneous Circulation (ROSC)

Interventions

Ventilation with a mechanical ventilator refers to connecting the patient to a ventilator (HAMILTON-T1 transport ventilator) after intubation, with the following settings: VCV mode, tidal volume of 6-

s chest rise during ventilation. A ZOLL monitor is used to estimate a tidal volume of 500-600 ml.

Experimental Device,Active Comparator Device

Mechanical ventilation ,Manual bag-valve-mask ventilation

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Out-of-hospital cardiac arrest patients aged 18 years and older 2. Attended by the Ramathibodi Hospital Emergency Medical Operations Unit over a period of one year after research approval (the first 6 months for manual bag-valve-mask ventilation and the following 6 months for mechanical ventilation).

Exclusion criteria

Exclusion criteria: 1. Patients who achieve return of spontaneous circulation before intubation or within 3 minutes after intubation 2. No venous or arterial blood gas results 3. Patients with cardiac arrest due to trauma 4. Suspected COVID-19 infection 5. Suspected pneumothorax 6. Pregnant women 7. Refusal of resuscitation 8. Refusal to participate or lack of consent

Design outcomes

Primary

Measure	Time frame
The efficacy of ventilation After receiving ventilation in the first 15 minutes or after ROSC (Return of Spontaneous Circulation). based on venous or arterial blood gas results (PaCO2)	—

Secondary

Measure	Time frame
The rate of sustained return of spontaneous circulation (lasting more than 20 minutes) and the 28-day survival rate. 20 minutes, 28 days Review medical record	—

Countries

Thailand

Contacts

Public ContactWelawat Tienpratarn

Faculty of Medicine, Ramathibodi Hospital, Mahidol University

welawat.tie@mahidol.edu0817022447

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026