Effects of different dosage of intravenous fentanyl for attenuating the hemodynamic response to endotracheal intubation in hypertensive patients

Effects of different dosage of IV fentanyl for attenuating hemodynamic response during intubation in hypertensive patients

Status

Unknown

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20241008003

Enrollment

Registered

2024-10-08

Start date

2023-11-13

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effects of different dosage of intravenous fentanyl for attenuating the hemodynamic response to endotracheal intubation in hypertensive patients. Hypertension Intubation Fentanyl Hemodynamic

Interventions

Administration of 2 microgram/kg of intravenous fentanyl 5 minutes before laryngoscopy and endotracheal tube insertion. ,Administration of 3 microgram/kg of intravenous fentanyl 5 minutes before laryn

Experimental Drug,Experimental Drug

2 mcg/kg of fentanyl,3 mcg/kg of fentanyl

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age 18-65 years old 2. ASA physical status II-III 3. Essential hypertension patients with well controlled hypertension 4. Scheduled for elective surgery under general anesthesia with direct laryngoscopy and endotracheal tube intubation without neuraxial anesthesia or peripheral nerve block 6. Peripheral vascular disease, heart disease 7. Impaired kidney function, GFR < 30 or ESRD 8. Blood pressure (BP) baseline > 140/90 mmHg 9. Diabetes mellitus with autonomic neuropathy 10. Expected duration of the operation shorter than 90 minutes 11. Rapid sequenced induction (RSI) technique is indicated.

Exclusion criteria

Exclusion criteria: 1. Anticipated difficult airway 2. Received anti-hypertensive drugs including beta-blocker, non-dihydropyridine CCB 3. Preoperatively opioids usage or abuse 4. Obesity BMI > 30 5. Pregnancy

Design outcomes

Primary

Measure	Time frame
Hemodynamic response 1 minute Difference in mean arterial pressure (MAP)	—

Secondary

Measure	Time frame
hemodynamic response 10 minutes Systolic blood pressure (SBP) mmHg,hemodynamic response 10 minutes Mean arterial pressure (MAP) mmHg,hemodynamic response 10 minutes Heart rate (HR) beat per minute,Incidence of hemodynamic instability including hypotension, arrythmia and unstable bradycardia 10 minutes EKG,Incidence of postoperative opioid overdose in PACU 10 minutes sedation score, pupil size, respiratory rate,Incidence of postoperative nausea and vomiting (PONV) in PACU 10 minutes score	—

Measure

Time frame

hemodynamic response 10 minutes Systolic blood pressure (SBP) mmHg,hemodynamic response 10 minutes Mean arterial pressure (MAP) mmHg,hemodynamic response 10 minutes Heart rate (HR) beat per minute,Incidence of hemodynamic instability including hypotension, arrythmia and unstable bradycardia 10 minutes EKG,Incidence of postoperative opioid overdose in PACU 10 minutes sedation score, pupil size, respiratory rate,Incidence of postoperative nausea and vomiting (PONV) in PACU 10 minutes score

—

Countries

Thailand

Contacts

Public ContactTanatporn Worratarakul

Deparment of Anesthesiology, Khon Kaen University

pimtnp@gmail.com0956633177

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026