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Randomized Clinical Trials of Intraocular Pressure-Lowering Medications on Preventing Spikes in Intraocular Pressure Following Intravitreal Anti-Vascular Endothelial Growth Factor Injections

The difference of IOP post intra vitreous injection among preoperative COSOPT, Combigan and Simbrinza instillation

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20241005001
Enrollment
300
Registered
2024-10-05
Start date
2020-12-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Retinal disease patients with indicated treatment with intravitreal anti-VEGF injections Anti-vascular endothelial growth factor (VEGF) Fixed combination anti-glaucoma medication Intraocular pressure spike Intravitreal injections Prophylactic anti-glaucoma medication

Interventions

The IOP-lowering medications were given 1 h before intravitreal anti-VEGF injections in the one-drop regimen, and 1 h and 5 min before intravitreal anti-VEGF injections for the two-drop regimen.,The I
dorzolamide-timolol,brimonidine /timolol ,brinzolamide/brimonidine,controll

Sponsors

Mettapracharak (Wat Rai Khing) hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: participant who had indicated treatment with intravitreal anti-VEGF injections (bevacizumab, aflibercept and ranibizumab)

Exclusion criteria

Exclusion criteria: 1.participants who required an intracameral drainage 2.participants who allergy to the drugs and their components used in this study as well as fluoroquinolone, sulfamycin, and anti-VEGF 3. participants who underlying diseases of asthma, chronic obstructive pulmonary disease (COPD), and heart disease, corneal diseases 4.participants who treatment of intravitreal steroid injections within the past three months.

Design outcomes

Primary

MeasureTime frame
intraocular pressure 30 mins and 1 hour I care tonometry

Secondary

MeasureTime frame
n/a n/a n/a

Countries

Thailand

Contacts

Public Contactkulawan rojananuangnit

Mettapracharak (Wat Rai Khing) hospital

kulakwan@icloud.com66819179192

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026