patients with hypertension presenting albuminuria more than 30 mg/g and taking more than one antihypertensive class more than 3 months albuminuria, albumin creatinine ratio, evening, hypertension, morning
Conditions
Interventions
taking antihypertensive pills in the morning at 6.00 to 10.00 am
,taking antihypertensive pills in the evening at 18.00 to 22.00 pm
Active Comparator Drug,Active Comparator Drug
Morning group,Evening antihypertensive drugs
Sponsors
Navamindradhiraj University, Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. age 18-80 years 2. diagnosis of hypertension more than 1 year 3. At least one antihypertensive agent for more than 3 months 4. At least one antihypertensive agent in Angiotensin-converting enzyme inhibitor (ACEI) and/or Angiotensin receptor blocker (ARB) 5. Well controlled blood pressure (systolic blood pressure < 150 mmHg, Diastolic blood pressure < 90 mmHg) 6.albuminuria > 30 mg/g 7.Renal function (estimated glomerular filtration rate, eGFR > 15 ml/min/1.73 m2)
Exclusion criteria
Exclusion criteria: End stage kidney disease Poor control blood pressure Severe comorbid disease for example congestive heart failure, active cancer Pregnancy Inflammatory disease or active infection for example arthritis, pyelonephritis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Log urine albumin creatinine ratio 3 months after intervention log UACR, mg/g | — |
Secondary
| Measure | Time frame |
|---|---|
| kidney function 3 months after intervention eGFR, mL/min/1.73 m2, Decreased in eGFR of 15% or more from baseline,Effects of blood pressure 3 months after intervention Blood pressure control ,Decreased in UACR 3 months after intervention Decreased in UACR of 30% or more from baseline | — |
Countries
Thailand
Contacts
Public ContactThanpisit Trakarnvanich
Faculty of Medicine, Navamindradhiraj University
Outcome results
None listed