Patients allergic or intolerant to the interventional drugs used Patients with severe liver, kidney, and cardiovascular disease Patients with open wounds or chronic skin disease such as psoriasis, chronic dermatitis etc. Esflurbiprofen transdermal patch Topical NSAID for postoperative analgesia Post-operative pain management in spinal fusion
Conditions
Interventions
Esflurbiprofen transdermal patch is an anti-inflammatory preparation for topical use that contained 40 mg of Esflurbiprofen.
,Medicated plaster administration is a unique preparation that provides lo
Active Comparator Drug,Placebo Comparator Drug
Esflurbiprofen transdermal patch,Medicated plaster
Sponsors
ourself
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients > 18 years with a lumbar degenerative disease with surgical indications (including spondylolisthesis, lumbar instability, lumbar spinal stenosis, etc.) Multisegmental fusion of the lumbar spine with instrumentation (2-3 levels).
Exclusion criteria
Exclusion criteria: A history of previous lumbar surgery A history of opioids used to control pain within 30 days Patients allergic or intolerant to the interventional drugs used Patients with severe liver, kidney, and cardiovascular disease Patients with open wounds or chronic skin disease such as psoriasis, chronic dermatitis etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphine consumption the first 12 hours, between 12-24 hours, 24-48 hours Cumulative dose | — |
Secondary
| Measure | Time frame |
|---|---|
| Post-operative pain 8 hours, 16 hours, 24 hours, 36 hours, 48 hours, and 72 hours postoperatively VAS | — |
Countries
Thailand
Contacts
Public ContactTerdpong Tanaviriyachai
Department of Orthopaedics, Maharat Nakhon Ratchasima Hospital.
Outcome results
None listed