Children with transfusion-dependent thalassemia Thiamin deficiency, children, transfusion-dependent thalassemia, oxidative stress
Conditions
Interventions
Pediatric patients with transfusion-dependent thalassemia
Screening
Pediatric thalassemia patients
Sponsors
Faculty of Medicine, Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
7 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Children aged 7 years to less than 18 years 2. Children who has been diagnosed with transfusion-dependent thalassemia and have received regular blood transfusion at least 12 months at Siriraj Hospital 3. Eligible to understand Thai language 4. Eligible to record food intake
Exclusion criteria
Exclusion criteria: 1. Have a problem of thiamin absorption e.g., underwent bariatric surgery 2. Receive probiotic supplement containing strains that can produce thiamin 3. Experienced critical illness less than 1 month 4. Have other co-morbidities requiring diuretic drugs 5. Had recent infection within two weeks 6. Have other hematologic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional assay of erythrocyte transketolase activity (ETKA) at enrollment ETKA is measured using the nicotinamide-adenine dinucleotide (NADH)-dependent method | — |
Secondary
| Measure | Time frame |
|---|---|
| Thiamin pyrophosphate level at enrollment High performance liquid chromatography,Diuretic use at enrollment Record review,Malondialdehyde at enrollment Calorimetric assay,Total antioxidant capacity at enrollment Calorimetric assay,Dietary intake At enrollment, a certified dietitian provided instructions. The data on energy and nutrients were then analyzed using INMUCAL-Nutrients V.4.0 computer software Calculation from a 5-day prospective food diary | — |
Countries
Thailand
Contacts
Public ContactNarumon Densupsoontorn
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed