Efficacy of fractional CO2 laser and product containing umbilical cord lining extract for periorbital rhytides: a prospective, randomized, split-face study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20240924009

Enrollment

Registered

2024-09-24

Start date

2024-03-15

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periorbital static rhytides fractional CO2 laser and umbilical cord lining extract for periorbital static rhytides

Interventions

- Three sessions of fractional CO2 laser at 1-month interval - The protocol of fractional CO2 laser : a single pass of 10,600 nm fractional CO2 laser (Lutronic Corp., Goyang, Korea) over the periorb

Power 30 W

Density 150 dot/cm2) - Immediately after the procedure was completed, one side of the periorbital region was randomly treated with product containing umbilical cord lining extract - Patients were aske

Density 150 dot/cm2) - Immediately after the procedure was completed, the other side of the periorbital region was treated with petroleum jelly. - Patients were asked to continue applying the assigned

Active Comparator Drug,Placebo Comparator Drug

fractional CO2 laser and product containing umbilical cord lining extract,fractional CO2 laser and petroleum jelly

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Healthy participants with periorbital static rhytides graded as 1-4 on photonumeric rating scale

Exclusion criteria

Exclusion criteria: - Major underlying medical conditions - Pregnancy - Lactation - Active skin disorders or recurrent herpes infection in the experimental region - A history of allergic response to umbilical cord extract or local anesthesia - A history of periorbital rhytides treatment within 6 months.

Design outcomes

Primary

Measure	Time frame
The degree of static wrinkles week 4, week 8, and week 12 Indentation index (small and medium filter) using Antera 3D	—

Secondary

Measure	Time frame
Improvement score by participants week 4, week 8, and week 12 10-cm visual analogue scale improvement score,Improvement score by a blinded physician week 4, week 8, and week 12 10-cm visual analogue scale improvement score	—

Countries

Thailand

Contacts

Public ContactVasanop Vachiramon

Faculty of Medicine, Ramathibodi hospital

vasanop@gmail.com6622011211

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026