High-dose versus Low-dose Intravenous Nitroglycerin on Intubation Rate of Sympathetic Crashing Acute Pulmonary Edema in the Emergency Department

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20240923005

Enrollment

140

Registered

2024-09-23

Start date

2024-11-06

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sympathetic crash acute pulmonary edema sympathetic crash acute pulmonary edema SCAPE nitroglycerine

Interventions

nitroglycerine 600 to 1000 mcg IV bolus then 100 mcg per min then titrate to achieve goal ,nitroglycerine 20-40 mcg per min then titrate to achieve goal

Experimental Drug,Active Comparator Drug

High dose nitroglycerine,Standard dose nitroglycerine

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adult more than 18 years old with diagnosis of sympathetic crash acute pulmonary edema (according to diagnosed criteria)

Exclusion criteria

Exclusion criteria: 1. Cardiac arrest 2. Shock which are mean arterial pressure lower than 65 mmHg with signs of poor tissue perfusion 3. Intubation 4. Acute myocardial infarction 5. Acute aortic dissection 6. Pregnancy 7. Those who allergic to nitroglycerine or with absolute contraindication

Design outcomes

Primary

Measure	Time frame
Intubation 24 hours percent rate	—

Secondary

Measure	Time frame
resoltion of symptom 4 hours percent rate,Admission 24 hours percent rate,Complication Any time percent rate	—

Countries

Thailand

Contacts

Public ContactUsapan Surabenjawong

Department of Emergency Medicine, Siriraj Hospital Faculty of Medicine

usapan.sur@mahidol.ac.th024199216

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026