Use of a Negative Pressure Trigger to Predict Successful Extubation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20240918006

Enrollment

Registered

2024-09-18

Start date

2020-10-13

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mechanically ventilated patients extubation mechanical ventilation respiratory failure weaning liberation respiratory muscle strength

Interventions

ability to initiate a breath under a negative pressure trigger set at -20 cmH2O, TAP-20,inability to initiate a breath under a negative pressure trigger set at -20 cmH2O ,TAP-20

Prevention,Prevention

Trigger achievement group,Trigger failure group

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age over 18 years 2. Current use of a ventilator with pressure triggering 3. a decision by the attending physician to extubate within 24 hours 4. adequate neurologic status Glasgow Coma Scale equal or more than 11 points 5. hemodynamic stability systolic blood pressure more than 90 mmHg 6. having received the minimal dose of vasoactive drugs 7. heart rate equal or less then 140 per min 8. SpO2 more than 90 percent while using fraction of inspired oxygen equal or less than 0.4 9. positive end-expiratory pressure equal or less then 8 cmH2O 10. respiratory rate equal or less then 35 per min 11. effective cough evaluated by physician in charge

Exclusion criteria

Exclusion criteria: 1. tracheostomy patients 2. progressive neuromuscular disease 3. on home mechanical ventilation 4. recent myocardial infraction within one month 5. decompensated heart failure with ejection fraction less than 30 percent 6. upper airway obstruction 7. excessive secretion 8. having received sedation or a neuromuscular blocking agent within 24 hours 9. arrhythmia

Design outcomes

Primary

Measure	Time frame
The diagnostic performance of TAP-20 in predicting successful extubation Day 1 sensitivity and specificity	—

Secondary

Measure	Time frame
Explanatory model for TAP-20 predicting successful extubation Day 1 Multivariable logistic regression,Diagnostic performance of TAP-20 compared to those of MIP, RSBI, and diaphragmatic ultrasound. Day 1 AUC under ROC	—

Countries

Thailand

Contacts

Public ContactPailin Ratanawatkul

Khon Kaen University

pailin@kku.ac.th66855534517

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026