neck wrinkles skin aging, erbium, biostimulators
Conditions
Interventions
1550nm Erbium laser (NAFL) (Finescan 1550, Agfa HealthCare, Belgium) with energy settings adjusted according to the participant'
s skin color, with energy values in the following range: Pulse energy: 10-40 mJ, Spot delivery: 100-300 dots/cm squared, using a handpiece tip size of 2.5, 4, or 7 cm squared, Power: 4 watts, Operatin
PDLLA + Erbium laser,Erbium laser
Sponsors
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Ramathibodi Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Must be at least 18 years old. 2. In good health with no serious chronic diseases. 3. Have visible horizontal wrinkles on the neck area (horizontal neckline) or be classified as Class 2-3 according to the Fitzpatrick-Goldman Classification of Wrinkling, or Grade 2-4 according to the Horizontal Neck Wrinkles Severity Scale. 4. Have skin type 3-5 according to Fitzpatrick Skin Type. 5. Able to attend scheduled medical appointments and comply with research protocols. 6. Willing to participate in the research by signing a consent form.
Exclusion criteria
Exclusion criteria: 1. Have obesity (BMI more than 25). 2. Have received treatment for neck wrinkles with laser, ultrasound, radiofrequency, or any type of filler within 1 year prior to the treatment, and with Botulinum Toxin injections within 6 months. 3. Use neck skincare products with collagen-stimulating properties, such as creams containing retinol or retinoids, or Vitamin C. 4. Have a skin infection in the neck area, such as fungal infections (tinea corporis) or bacterial infections (impetigo, erythrasma, folliculitis, or abscess), or inflammatory skin conditions such as irritant contact dermatitis or allergic contact dermatitis that has not been treated for at least 1 month before the treatment. 5. Have open wounds or sores in the neck area. 6. Have a history of chronic skin conditions in flare-ups, such as psoriasis, cutaneous lupus erythematosus, eczema, vitiligo, or rosacea. 7. Have a history of skin cancer. 8. Have a history of keloid scarring. 9. Have a history of recurrent herpes infections. 10. Have a chronic condition related to abnormal blood clotting (easy bleeding, difficulty stopping bleeding) or are currently using anticoagulants or thrombolytic drugs. 11. Have a history of allergic reactions to PDLLA of any severity. 12. Are pregnant or breastfeeding. 13. Refuse to participate or withdraw from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antera3D camera day 0, 30, 60, 90, 120, 150 Wrinkle (indentation index), texture, Hb, melanin, Pore],Delfin day 0, 30, 60, 90, 120, 150 Multiprobe moisture meter) [Hydration, TEWL,Horizontal neck wrinkle severity score day 0, 30, 60, 90, 120, 150 Horizontal neck wrinkle severity score,itzpatrick Goldman Classification of Wrinkling day 0, 30, 60, 90, 120, 150 itzpatrick Goldman Classification of Wrinkling,Fitzpatrick Goldman Classification of Degree of Elastosis Scale day 0, 30, 60, 90, 120, 150 Fitzpatrick Goldman Classification of Degree of Elastosis Scale,Global Aesthetic Improvement Scale Score (GAIS) day 0, 30, 60, 90, 120, 150 Global Aesthetic Improvement Scale Score (GAIS),assessment by patients day 0, 30, 60, 90, 120, 150 Pain score, satisfaction score (Visual analogue score) | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events day 0, 30, 60, 90, 120, 150 Adverse events (descriptive) | — |
Countries
Thailand
Contacts
Public ContactVasanop Vachiramon
Division of Dermatology, Department of Medicine Faculty of Medicine, Ramathibodi Hospital
Outcome results
None listed