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Effect of Intraoperative Dexmedetomidine on Propofol Requirement in Children Undergoing Elective Daycare Surgery

Effect of Intraoperative Dexmedetomidine Infusion on Propofol Requirement in Children Undergoing Elective Daycare Surgery Under TCI-Powered Total Intravenous Anaesthesia: A Randomised Controlled Study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20240917002
Enrollment
100
Registered
2024-09-17
Start date
2024-10-09
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients undergoing infraumbilical daycare surgery infraumbilical daycare surgery TIVA TCI emergence delirium

Interventions

Patient will receive Dexmedetomidine loading dose at 0.5 mcg/kg followed by 0.3 mcg/kg/hour infusion + propofol-TCI set at plasma target value of 3 mcg/ml at induction, later adjusted to maintain a BI
Active Comparator Drug,Active Comparator Drug
GROUP DEXMEDETOMIDINE-PROPOFOL,GROUP PROPOFOL

Sponsors

SIR GANGA RAM HOSPITAL
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 12 Years

Inclusion criteria

Inclusion criteria: 1.patients undergoing infraumbilical daycare surgery 2. ASA physical status I/II

Exclusion criteria

Exclusion criteria: 1. Parent or guardian's refusal 2. ASA status III or IV 3. Known allergy/hypersensitivity to the study drug 4. Difficult intravenous access or refusal to iv cannulation while being awake 5. Any developmental delay or neuropsychiatric illness 6. Obese children (more than/ equal to 95 percentile of BMI age appropriate) 7. Congenital heart disease or coagulation disorder

Design outcomes

Primary

MeasureTime frame
Total dose of propofol at the end of surgery Paedfuser machine

Secondary

MeasureTime frame
intraoperative haemodynamics every 5 minutes intraoperatively drager monitor,post operative sedation 30 minutes, 1 hour, 2 hour post operatively observing the patient,time of discharge from post anesthesia care unit 2 hours post operatively observing the patient

Countries

India

Contacts

Public ContactDEEPANJALI PANT

SENIOR CONSULTANT

deepanjalipant@gmail.com09674199344

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026