skin quality hyaluronic acid, radiofrequency therapy, rejuvenation, esthetics, wrinkles, skin aging
Conditions
Interventions
Radiofrequency microneedling (Potenza, Jeisys Medical Inc., Korea) with the CP-21 tip, which consists of 21 insulated needles that can adjust to a depth of 0.75 millimeters, with a central diameter of
Experimental Other,Active Comparator Other
Radiofrequency microneedling and non crossed linked hyaluronic acid,Radiofrequency microneedling and NSS
Sponsors
Dermatology Branch, Department of Internal Medicine, Faculty of Medicine, Ramathibodi Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 65 years. 2. In good health with no severe chronic illnesses. 3. Presence of enlarged pores, wrinkles, or uneven skin tone on both sides of the face. 4. Able to attend scheduled appointments with the physician and adhere to the research protocol. 5. Willing to participate in the research by providing signed consent.
Exclusion criteria
Exclusion criteria: 1. Presence of infection or inflammation in the skin area where the treatment will be conducted. 2. Presence of wounds or open sores in the area where the treatment will be conducted. 3. Having an autoimmune disorder. 4. History of skin cancer. 5. Presence of uncontrolled inflammatory acne (Acne vulgaris). 6. History of keloid scarring. 7. History of allergic reactions to anesthetics, dermal fillers, or non-crosslinked hyaluronic acid. 8. Underwent surgery in the treatment area within 6 months prior to the study. 9. Received laser treatment, dermabrasion, peeling, radiofrequency, or focused ultrasound in the treatment area within 3 months prior to the study. 10. Received filler injections in the treatment area within 1 year. 11. History of trauma with metal implants in the treatment area. 12. History of recurrent herpes simplex virus infection. 13. Used vitamin A derivatives within the past 3 months. 14. History of COVID-19 infection within the past 14 days before the start of the study. 15. History of root canal disease or dental procedures. 16. Pregnant women or women who are breastfeeding. 17. Refusal or withdrawal from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pore size 1 before and immediately after and 4,8,12 weeks after first treatment antera 3D skin analysis device,pore size 2 before and immediately after and 4,8,12 weeks after first treatment Criteria of visual assessment for pore of images taken using visia device,wrinkle 1 before and immediately after and 4,8,12 weeks after first treatment antera 3D skin analysis device,wrinkle 2 before and immediately after and 4,8,12 weeks after first treatment Lemperle's scale of images taken using visia device,Transepidermal Water Loss before and immediately after and 4,8,12 weeks after first treatment VapoMeter,Skin Hydration Measurement before and immediately after and 4,8,12 weeks after first treatment Moisture Meter,pain score after treatment at week 0,4,8 visual analogue score,overall improvement week 4,8,12 visual analogue score | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse events immediately after and 4,8,12 weeks after first treatment evaluation by dermatologist for bruise, discolouration, scar, hematoma etc. | — |
Countries
Thailand
Contacts
Public ContactVasanop Vachiramon
Dermatology Branch, Department of Internal Medicine, Faculty of Medicine, Ramathibodi Hospital
Outcome results
None listed