Bradycardia in patients with dementia and mild cognitive impairment (MCI) receiving cholinesterase inhibitors. Geriatric, Cholinesterase inhibitors, Bradycardia, Dementia, Falls, QT interval
Conditions
Interventions
Patients diagnosed with dementia or mild cognitive impairment who were prescribed cholinesterase inhibitors ChEIs during the study period. This group may include patients who also received memantine i
Diagnostic,Diagnostic
Cholinesterase Inhibitor ChEI Group,Non-Cholinesterase Inhibitor (Non-ChEI) Group
Sponsors
Faculty of Medicine, Ramathibodi Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged 60 years and older 2. Diagnosed with dementia or mild cognitive impairment (MCI) 3. Mean baseline heart rate of less than 60 bpm Minimum of three recorded heart rate measurements within the six months prior to the index date
Exclusion criteria
Exclusion criteria: 1. Patients with fewer than three recorded heart rate measurements during the six-month period prior to the index date 2. Presence of a pacemaker 3. Patients with high-grade atrioventricular (AV) block
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bradycardia related adverse evenets 12 months after index dates events | — |
Secondary
| Measure | Time frame |
|---|---|
| ECG abnormalities 12 months from index date ECG changes | — |
Countries
Thailand
Contacts
Public ContactSmuch Siramongkholkarn
Ramathibodi Hospital
Outcome results
None listed