Does intraosseous morphine administration reduce pain and morphine consumption after total knee arthroplasty: A prospective randomized, double-blind, placebo-controlled trial

Status

Unknown

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20240908002

Enrollment

Registered

2024-09-08

Start date

2024-08-12

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post-operative pain and morphine consumption after total knee arthroplasty intraosseous morphine, pain, total knee arthroplasty

Interventions

All patients will receive anesthesia administered by an anesthesiologist using the following methods: Spinal Block: Morphine 2.5-3 mg, depending on the patient&#039

s height, the rate of injection, and the duration of surgery. Ultrasound-Guided Adductor Canal Block: 0.5% Marcaine 20 cc + Dexamethasone 5 mg. Prophylaxis for nausea and vomiting should be avoided.

s height, the rate of injection, and the duration of surgery. Ultrasound-Guided Adductor Canal

Experimental Drug,Placebo Comparator No treatment

intraosseous morphine,NSS(placebo)

Eligibility

Sex/Gender

All

Age

1 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients under 80 years old who have been diagnosed with primary osteoarthritis and have undergone unilateral primary total knee arthroplasty (TKA) at Siriraj Hospital. 2. Able to understand and communicate in Thai.

Exclusion criteria

Exclusion criteria: 1. Patients with a history of drug allergies or contraindications related to the research process, including: - Anesthetics: Morphine, Marcaine, Dexamethasone - Pain relievers: Bupivacaine, Ketorolac, Paracetamol with Codeine, Norgesic, Parecoxib, Etoricoxib - Other drugs: Omeprazole, Metoclopramide - NSAIDs: Patients with recent CAD, stroke, GI bleeding, on anticoagulants, dual antiplatelet therapy, or uncontrolled hypertension - Norgesic: Patients with BPH, dementia 2. Estimated glomerular filtration rate (eGFR) less than 60. 3. Patients with severe liver impairment (Child-Pugh Class C). 4. Patients diagnosed with a psychiatric disorder. 5. Patients with knee deformities with valgus or varus angles greater than 20 degrees. 6. Patients undergoing complex primary total knee arthroplasty (using a revision system). 7. Patients experiencing severe pain after discontinuation of opioid medications before surgery or unable to control preoperative pain without opioids. 8. Patients who do not consent to the specified anesthesia techniques, such as spinal block or adductor canal block.

Design outcomes

Primary

Measure	Time frame
pain 48 hours after intervention numeric rating scale	—

Secondary

Measure	Time frame
morphine consumption 48 hours after intervention mg	—

Countries

Thailand

Contacts

Public ContactThanapat Trongnipat

Faculty of medicine, Siriraj hospital

tdskywalkker@gmail.com0982936565

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026