Women Healthy condition without severe illness, and will during dysmenorrhea. Ginger, Functional ingredient, Functional food, Healthy women
Conditions
Interventions
The group consume gummies without ginger extract 1 serving/day for 6 weeks.,The group consume gummies containing ginger extract 250 mg/serving/day for 6 weeks.,The group consume gummies containing gin
Placebo,Ginger Gummies 250 mg/serving,Ginger Gummies 500 mg/serving
Sponsors
Program Management Unit Competitiveness (PMUC)
Eligibility
Sex/Gender
Female
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Healthy female volunteers aged 18-35 years 2. Have dysmenorrhea symptoms in the past 6 months, have a pain score assessed by the 11-point numerical rating scale (NRS) in the range of 4 less than pain score less than 11 3. Have had a regular menstrual period in the past 3 months 4. Can communicate, read and write in Thai language.
Exclusion criteria
Exclusion criteria: 1. Have chronic diseases that require continuous medication, such as cardiovascular disease or blood clot obstruction, lung disease, thyroid disease, adrenal gland, pituitary gland, cancer, diabetes, allergies, liver disease, chronic kidney disease (estimate GFR less than 60 mL/min/1.73m2), and have a history of brain injury. 2. Take cholesterol-lowering drugs, blood sugar-lowering drugs Antihypertensive drugs or drugs that interfere with platelet function, such as aspirin and nonsteroidal anti-inflammatory drugs 3. Taking general antibiotics or Paracetamol, which have pain-reducing effects 4. Taking birth control pills or hormones or calcium or vitamin D supplements or herbs regularly 5. Being pregnant or having a history of uterine abnormalities (fibroids, polyps, endometrial hypertrophy, and endometriosis) or ovarian abnormalities 6. Having given birth less than 32 weeks ago 7. Having abnormal vaginal discharge or abnormal cervical cells 8. Having a history of hysterectomy or ovarian surgery (Hysterectomy and/or Oophorectomy) 9. Having depression or anxiety or high stress 10. Drinking more than 5 alcoholic drinks (1000 ml) per day 11. Smoking more than 10 cigarettes per day 12. Being involved in other human research projects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessing pain score Baseline, week 6th Using Numerical Rating Scale (NRS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Demorgraphic data Baseline, week 6th Vital sign, Electrocardiogram, Body Mass Index (BMI), Body Composition, Body Composition Analyzer, Anthropometry,Safety parameters Baseline, week 6th Hematology, Blood biochemical markers, Blood electrolytes by Hospital Laboratory,Oxidative stress markers (MDA, SOD, CAT, GPx, 8-OHDG, iNOS, Nrf2) Baseline, week 6th ELISA kis or Assay kits, HHPHP laboratory,Inflammatory markers (Il-6, NF-KB, TNF-alpha, COX2, PGF2alpha, PGE, PGF2alpha/PGE ratio Baseline, week 6th ELISA kis, HHPHP laboratory,Assessing Depression Anxiety Stress Baseline, week 6th Depression Anxiety Stress Scales (DASS-21) | — |
Countries
Thailand
Contacts
Public ContactWeerapon Sangartit
Faculty of Medicine, Khon Kaen University
Outcome results
None listed