Pediatric septic shock Pediatric septic shock hemoperfusion hemodynamic morbidity
Conditions
Interventions
An HA330 disposable hemoperfusion cartridge (HA330/HA60, Jafron, Zhuhai City, China) will be used with a continuous renal replacement therapy (CRRT) machine (Aquarius or Primaflex, or any other CRRT m
Experimental Device,No Intervention Other
Hemoperfusion with protocol,Control, with standard sepsis care
Sponsors
Jafron Biomedical Co., Ltd
Eligibility
Sex/Gender
All
Age
2 Weeks to 18 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of septic shock within 24 hours with the following criterias: Confirmed diagnosis of septic shock according to established criteria (e.g., Pediatric Sepsis Definition Task Force, International Pediatric Sepsis Consensus Conference, Goldstein et al 2005) Age range: Clearly define the age range of eligible participants (e.g., Infants age from 1 month to adolescents (18 years) admitted to PICU 2. Severity: Define specific severity criteria based on validated scoring systems like PRISM III, PELOD-2, or SOFA score to ensure enrollment of critically ill patients with a high risk of mortality.
Exclusion criteria
Exclusion criteria: 1 Underlying chronic conditions ( for example cardiac or renal failure, severe liver disease) 2 Known severe bleeding diathesis or active bleeding (platelet count less than 25,000 /mm3) 3 Previous exposure to hemoperfusion within previous 1 week 4 Known allergies to components of the hemoperfusion system 5 Severe multiple organ failure 6 Multiple congenital anomaly or end of life care
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical efficacy PICU duration vasopressor used, shock resolution,safety PICU admission bleeding at vital organs | — |
Secondary
| Measure | Time frame |
|---|---|
| survival PICU duration survival rate compare to control | — |
Countries
Thailand
Contacts
Public ContactRujipat Samransamruajkit
408-237709-5
Outcome results
None listed