Type 2 diabetes with Obesity Gut Microbiota Type 2 diabetes Obesity Gut Microbiota Hypocaloric diet
Conditions
Interventions
Participants received a 6-week hypocaloric diet ,followed by a 6-week weight maintenance period with a caloric intake of 1500-1800 kcal/day.,Participants received a normal diet of 1500-200 kcal/day th
Experimental Behavioral,No Intervention No treatment
Hypocaloric diet ,Control
Sponsors
Chulalongkorn University
The Endocrine Society of Thailand
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosed with type 2 diabetes within the previous 10 years 2.Body mass index more than 25 kg/m2 3.Glycated hemoglobin level between 6.5 and 10%
Exclusion criteria
Exclusion criteria: 1.Use of steroids 2.Previous use of insulin 3.Previous treatment with a glucagon-like peptide-1 receptor agonist in the past 3 months 4.Serum creatinine more than 1.5 ng/mL 5.Serum alanine aminotransferase more than 2.5 fold above the upper limit of the reference range. 6.Diagnosed with Inflammatory bowel disease 7.History of metabolic or bariatric surgery 8.Previous treatment with probiotics in the past 3 months 9.History of weight change of more than 5% in the past 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolic Parameters 0,6 and 12 week Blood sample | — |
Secondary
| Measure | Time frame |
|---|---|
| Change of gut microbiota 0,6 and 12 week Fecal collection | — |
Countries
Thailand
Contacts
Public ContactMongkontida Umphonsathien
Police General Hospital
Outcome results
None listed