Efficacy of 0.12% chlorhexidine mouthwash containing 0.001% EDTA versus commercially available chlorhexidine mouthwash in minimizing tooth staining: A randomized clinical trial

Comparison of the efficacy of 0.12% chlorhexidine mouthwash containing 0.001% EDTA and commercially available 0.12% chlorhexidine mouthwash: A randomized clinical trial

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20240830005

Enrollment

Registered

2024-08-30

Start date

2023-02-11

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis Dental devices Health behavior Periodontitis

Interventions

EDTA containing chlorhexidine mouthwash has been developed to minimize the unwanted effects of chlorhexidine such as extrinsic discoloration and bitter taste. ,CHX is powerful antibacterial and antip

Experimental Drug,Experimental Drug

0.12% chlorhexidine mouthwash containing 0.001% EDTA ,commercially available 0.12% chlorhexidine mouthwash

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Healthy adults aged 18-35 years 2. Healthy gingiva or gingivitis according to AAP/EFP, 2018 3. Absence of orthodontic appliance

Exclusion criteria

Exclusion criteria: 1. Smokers 2. Undergoing orthodontic treatment 3. Severe crowding of teeth 4. Ulcerative oral lesions 5. Allergy to chlorhexidine and/or EDTA 6. History of antibiotics use within the last 2 months prior to the study

Design outcomes

Primary

Measure	Time frame
tooth staining 2 weeks stain index	—

Secondary

Measure	Time frame
plaque formation and gingival inflammation 2 weeks plaque and gingival index	—

Countries

Thailand

Contacts

Public ContactSirada Jindamporn

Chulalongkorn University

siradapang@hotmail.com0853491503

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026