Preterm prelabour rupture of membranes (PPROM) Preterm prelabour rupture of membranes (PPROM) Latency period Azithromycin Maternal complications Neonatal complications
Conditions
Interventions
1. Ampicillin 2 g administered intravenously every 6 hours for 48 hours, followed by amoxicillin 250 mg administered orally every 8 hours for 5 days
2. Azithromycin 1 g administered orally once, follo
Placebo Comparator Drug,Experimental Drug
Group A,Group B
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Singleton pregnant women aged 18 years or older who were admitted to the labor room of the Department of Obstetrics and Gynaecology, Faculty of Medicine, Siriraj Hospital, with a diagnosis of preterm prelabour rupture of membranes (PPROM) at gestational age between 24 0/7 and 33 6/7 weeks.
Exclusion criteria
Exclusion criteria: - Intrauterine fetal demise - Multiple pregnancies - Major congenital fetal anomalies - History of hypersensitivity or allergy to penicillin or macrolides - Contraindications to expectant management, including clinical chorioamnionitis, placental abruption, nonreassuring fetal status, or advanced labor at the time of hospital admission (defined as active labour with cervical dilation of 4-6 cm or greater)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Latency period Duration between rupture of membranes to time of delivery (hours) Duration between rupture of membranes to time of delivery (hours) | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal adverse outcome after end of the intervention and postpartum period Number (case) of maternal adverse outcome,Neonatal adverse outcome Age of neonate between 0-28 days Number (case) of neonatal adverse outcome | — |
Countries
Thailand
Contacts
Public ContactMinmanta Chinnawutsritrakul
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed